RSV-infected children with mixed infections: clinical features and early predictive indicators of codetection with Streptococcus pneumoniae and Haemophilus influenzae - Takeaways - MDSpire

RSV-infected children with mixed infections: clinical features and early predictive indicators of codetection with Streptococcus pneumoniae and Haemophilus influenzae

  • By

  • Jingwen Ni

  • Junyu Dong

  • Lele Li

  • Mengxin Zhao

  • Zhihui Du

  • Jie Li

  • Kenan Fang

  • Kai-Sheng Hsieh

  • May 4, 2026

  • 0 min

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  • 1

    The study analyzed 1,601 children hospitalized with RSV, focusing on those codetected with Streptococcus pneumoniae and Haemophilus influenzae.

  • 2

    Children with S. pneumoniae codetection were more likely to present with fever, while those with H. influenzae showed increased wheezing and respiratory distress.

  • 3

    Elevated inflammatory markers, particularly IL-6, were significantly associated with bacterial codetection in RSV-infected children.

  • 4

    Children with bacterial codetection required more respiratory support, had higher PICU admission rates, and longer hospital stays compared to those without.

  • 5

    A history of wheezing and elevated IL-6 levels predicted S. pneumoniae codetection, while younger age and higher WBC and CRP levels predicted H. influenzae codetection.

Original Source(s)

RSV-infected children with mixed infections: clinical features and early predictive indicators of codetection with Streptococcus pneumoniae and Haemophilus influenzae

  • by Jingwen Ni, Junyu Dong, Lele Li, Mengxin Zhao, Zhihui Du, Jie Li, Kenan Fang, Kai-Sheng Hsieh

  • May 4, 2026

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