PPIB and its role in prostate cancer: associations with transcriptomic and splicing alterations - Takeaways - MDSpire
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The Role of PPIB in Prostate Cancer: Links to Transcriptomic Changes and Splicing Variations

  • By

  • Shuangyu Ma

  • Aikeshanjiang Ailiyaer

  • Huixiang Chen

  • Yishen Mao

  • Mulati Rexaiti

  • Abdureheman Zebibula

  • September 8, 2026

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  • 1

    PPIB mRNA expression is significantly elevated in prostate cancer tissues compared to non-tumor areas, as shown in TCGA-PRAD analysis.

  • 2

    PPIB knockdown in PC-3 cells resulted in suppressed proliferation, migration, invasion, and tumor growth in xenograft models.

  • 3

    Transcriptomic profiling revealed 570 differentially expressed genes and 873 alternative splicing events associated with PPIB depletion.

  • 4

    Joint analysis identified 22 shared genes between differentially expressed genes and splicing events, including metabolic regulators PHGDH and SHMT2.

  • 5

    Re-expression of shRNA-resistant PPIB restored migration and invasion capabilities reduced by PPIB knockdown in prostate cancer cells.

Original Source(s)

PPIB and its role in prostate cancer: associations with transcriptomic and splicing alterations

  • by Shuangyu Ma, Aikeshanjiang Ailiyaer, Huixiang Chen, Yishen Mao, Mulati Rexaiti, Abdureheman Zebibula

  • September 8, 2026

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