Real-world practices and challenges of radiologically isolated syndrome: results of a cross-sector survey by the DACH MS guidelines group

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A survey of 127 neurologists in the DACH region revealed significant variability in RIS management practices.
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Diagnostic approaches for RIS were largely uniform, with over 85% performing MRI and CSF analysis.
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Only 34% of neurologists consistently applied the 2023 RIS criteria, indicating a gap in guideline adherence.
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Structural barriers such as reimbursement challenges and limited specialist access were identified as key obstacles.
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The study highlights the urgent need for standardized guidelines to improve RIS diagnosis and treatment across the DACH region.

Frontiers In Neurology

by Friederike Held, Antonios Bayas, Katharina Christe, Christian Dettmers, Burkhard Domurath, Juliane Ebert, Edeltraud Faßhauer, Peter Flachenecker, Jutta Gärtner, Dzenita Hasanbasic, Christoph Heesen, Harald Hegen, Thomas Henze, Peter Huppke, Veronika Kana, Michael Khalil, Ruth Kirschner-Hermanns, Thomas Korn, Tania Kümpfel, Sabine Lamprecht, Uwe Meier, Gerd Meyer zu Horste, Mathias Mäurer, Frederike Cosima Oertel, Caroline Pot, Anne-Katrin Pröbstel, Kevin Rostásy, Anke Salmen, Jutta Scheiderbauer, Markus Schmidt, Erwin Stark, Corinna Trebst, Regina Trollmann, Clemens Warnke, Mike P. Wattjes, Benedikt Wiestler, Brigitte Wildemann, Uwe Zimmermann, Klaus Gehring, Achim Berthele, Bernhard Hemmer
July 14, 2026

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