Case Report: Recurrent abdominal pain with elevated pancreatic enzymes in type 2 diabetes mellitus: a case of IgG4-related autoimmune pancreatitis misdiagnosed as acute pancreatitis - Takeaways - MDSpire

Case Report: Recurrent abdominal pain with elevated pancreatic enzymes in type 2 diabetes mellitus: a case of IgG4-related autoimmune pancreatitis misdiagnosed as acute pancreatitis

  • By

  • Yaping Shi

  • Wanying Xue

  • Zhe Dai

  • Yuwen Wu

  • July 13, 2026

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  • 1

    IgG4-related autoimmune pancreatitis (IgG4-AIP) is often misdiagnosed as acute pancreatitis due to overlapping clinical features.

  • 2

    A 60-year-old male with type 2 diabetes presented with recurrent abdominal pain and elevated pancreatic enzymes, initially diagnosed with acute pancreatitis.

  • 3

    The diagnosis of IgG4-AIP was confirmed by markedly elevated serum IgG4 levels, atypical imaging findings, and a positive response to glucocorticoid therapy.

  • 4

    Timely measurement of serum IgG4 and integration of imaging and histopathology are crucial for the early diagnosis of IgG4-AIP.

  • 5

    Misdiagnosis of IgG4-AIP can delay treatment, emphasizing the need for awareness in patients with type 2 diabetes presenting with abdominal pain.

Original Source(s)

Case Report: Recurrent abdominal pain with elevated pancreatic enzymes in type 2 diabetes mellitus: a case of IgG4-related autoimmune pancreatitis misdiagnosed as acute pancreatitis

  • by Yaping Shi, Wanying Xue, Zhe Dai, Yuwen Wu

  • July 13, 2026

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