Ultraviolet radiation as a double-edged regulator of melanocyte function in vitiligo therapy and melanoma carcinogenesis - Takeaways - MDSpire

Ultraviolet radiation as a double-edged regulator of melanocyte function in vitiligo therapy and melanoma carcinogenesis

  • By

  • Heng-Heng Fan

  • Yan-Yan Chen

  • Yun Geng

  • Yi-Fei Yang

  • Hui Xu

  • Yu-Yun Xiong

  • Yun-Wen Zheng

  • Yu-Mei Li

  • June 1, 2026

  • 0 min

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  • 1

    Vitiligo is a chronic autoimmune disorder marked by melanocyte loss and progressive skin depigmentation.

  • 2

    Narrowband ultraviolet B (NB-UVB) therapy is a standard treatment for inducing repigmentation in vitiligo patients.

  • 3

    Excessive ultraviolet radiation (UVR) can lead to melanocyte dysfunction, photoaging, and increased cancer risk.

  • 4

    UVR has dual effects on melanocytes, promoting pigmentation while also inducing oxidative stress and genomic instability.

  • 5

    Combination therapies, including JAK inhibitors and platelet-rich plasma, are being explored to enhance vitiligo treatment.

Original Source(s)

Ultraviolet radiation as a double-edged regulator of melanocyte function in vitiligo therapy and melanoma carcinogenesis

  • by Heng-Heng Fan, Yan-Yan Chen, Yun Geng, Yi-Fei Yang, Hui Xu, Yu-Yun Xiong, Yun-Wen Zheng, Yu-Mei Li

  • June 1, 2026

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