In-vitro flow assessment study of intra-saccular endovascular devices for brain aneurysm treatment: SEAL™ vs. WEB™

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The study evaluated flow dynamics of SEAL™ and WEB™-SL devices using particle image velocimetry in a patient-specific aneurysm model.
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Mean residence time increased significantly with SEAL-BASE and SEAL-ARC compared to control and WEB-SL, indicating altered flow dynamics.
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Vorticity strength decreased significantly with SEAL devices compared to control, highlighting their effectiveness in disrupting aneurysmal flow.
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Velocity magnitude dropped significantly with SEAL devices compared to control and WEB-SL, with SEAL-BASE showing the greatest reduction.
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Results suggest that SEAL configurations achieve greater flow reduction than WEB-SL, emphasizing the potential for optimizing neurointerventional devices.

Frontiers In Neurology

by Hamid Mansouri, Nedim Gulkaya, Matthew J. Gounis, Mohammad AlMajali, Amit Chaudhari, Darwin G. Ramirez Abreu, Syed F. Zaidi, Yazan K. Ashouri, Naoki Kaneko, Brian T. Jankowitz, David J. Altschul, Boris Pabon, Pervinder Bhogal, Thomas J. Wolfe, Edgard L. Pereira, Aamir Badruddin, Laila Ibrahim, Omid Amili, Osama O. Zaidat
June 19, 2026

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