Trends of Enteric Fever and Emergence of Extensively Drug-Resistant Typhoid in Pakistan: Population-Based Laboratory Data From 2017–2019 - Takeaways - MDSpire

Trends of Enteric Fever and Emergence of Extensively Drug-Resistant Typhoid in Pakistan: Population-Based Laboratory Data From 2017–2019

  • By

  • Farah Naz Qamar

  • Mohammad Tahir Yousafzai

  • Ibtisam Qazi

  • Sonia Qureshi

  • Naor Bar-Zeev

  • Shazia Sultana

  • Muhammad Jawwad

  • Aneeta Hotwani

  • Seema Irfan

  • Muhammad Ashraf Memon

  • Irim Iftikhar

  • Summiya Nizamuddin

  • Ikram Ujjan

  • Ejaz Ahmed Khan

  • Mohsina Noor Ibrahim

  • March 5, 2025

  • 0 min

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  • 1

    Enteric fever, caused by Salmonella Typhi and Paratyphi, remains prevalent in low- and middle-income countries, particularly affecting children.

  • 2

    A retrospective review of 464,956 blood cultures from 2017 to 2019 revealed a 5% isolation rate of Typhi and Paratyphi in Pakistan.

  • 3

    The highest proportion of S. Typhi cases was found in Sindh (72%), with the 5–14 years age group showing the highest resistance rates.

  • 4

    Resistance to first-line antibiotics was significant, with 57% of S. Typhi isolates classified as extensively drug-resistant (XDR) by 2019.

  • 5

    S. Paratyphi isolates remained largely responsive to antibiotics, with high susceptibility rates to ampicillin, chloramphenicol, and ceftriaxone.

Original Source(s)

Trends of Enteric Fever and Emergence of Extensively Drug-Resistant Typhoid in Pakistan: Population-Based Laboratory Data From 2017–2019

  • by Farah Naz Qamar, Mohammad Tahir Yousafzai, Ibtisam Qazi, Sonia Qureshi, Naor Bar-Zeev, Shazia Sultana, Muhammad Jawwad, Aneeta Hotwani, Seema Irfan, Muhammad Ashraf Memon, Irim Iftikhar, Summiya Nizamuddin, Ikram Ujjan, Ejaz Ahmed Khan, Mohsina Noor Ibrahim

  • March 5, 2025

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