Pregnane X receptor (NR1I2) deficiency in mice reveals context-dependent regulation of inflammatory homeostasis - Takeaways - MDSpire

Pregnane X receptor (NR1I2) deficiency in mice reveals context-dependent regulation of inflammatory homeostasis

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1

NR1I2, or PXR, is a ligand-activated transcription factor involved in xenobiotic metabolism and inflammation regulation.
2

Complete Nr1i2 knockout disrupts intestinal homeostasis and increases innate immune activation, worsening intestinal damage.
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Tissue-specific deletion of Nr1i2 does not replicate the whole-body knockout phenotypes, indicating context-dependent functions.
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Pharmacological stimulation of Nr1i2 can provide protective benefits, highlighting its role as an immune-metabolic integrator.
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NR1I2 is crucial for coordinating detoxification, microbial signal sensing, and modulation of inflammatory pathways.