Type B insulin resistance with glycemic extremes: a case report and literature review - Takeaways - MDSpire

Type B insulin resistance with glycemic extremes: a case report and literature review

  • By

  • Emmeline Monique T. Ngo

  • Jordan M. Rowe

  • Thilo Samson Chillon

  • Lutz Schomburg

  • Rebecca J Brown

  • Shourya Tadisina

  • May 22, 2026

  • 0 min

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  • 1

    Type B insulin resistance (TBIR) is a rare autoimmune disorder characterized by IgG autoantibodies targeting the insulin receptor.

  • 2

    A 20-year-old Hispanic woman with TBIR presented with diabetic ketoacidosis and extreme insulin resistance requiring over 5,000 units of insulin daily.

  • 3

    Treatment included high-dose insulin, GLP-1 receptor agonist semaglutide, and immunosuppressive therapy, leading to significant insulin requirement reduction.

  • 4

    The case highlights the biphasic glycemic course of TBIR, with initial hyperglycemia followed by antibody-induced hypoglycemia.

  • 5

    Early diagnosis and individualized immunosuppressive regimens are crucial for optimizing outcomes in patients with TBIR.

Original Source(s)

Type B insulin resistance with glycemic extremes: a case report and literature review

  • by Emmeline Monique T. Ngo, Jordan M. Rowe, Thilo Samson Chillon, Lutz Schomburg, Rebecca J Brown, Shourya Tadisina

  • May 22, 2026

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