The time-effect relationship of intra-articular ozone injection for knee osteoarthritis: a systematic review and meta-analysis - Takeaways - MDSpire

The time-effect relationship of intra-articular ozone injection for knee osteoarthritis: a systematic review and meta-analysis

  • By

  • Fengjiao Chen

  • Yufeng Tao

  • Jing Deng

  • Leyi Zhang

  • Lanlan Yu

  • Zhuoxi Yang

  • Yixuan Zhang

  • Chi Zhang

  • June 17, 2026

  • 0 min

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  • 1

    Intra-articular ozone therapy effectively alleviates symptoms of knee osteoarthritis in the short term, particularly at 1 and 2 months post-treatment.

  • 2

    Meta-analysis of 16 randomized controlled trials involving 1,172 patients demonstrated significant symptom improvement at 1 and 2 months.

  • 3

    By 3 months, the therapeutic effects of ozone therapy diminish, with no significant differences observed in outcomes.

  • 4

    At 6 and 12 months, ozone therapy showed inferior outcomes compared to active control therapies like hyaluronic acid.

  • 5

    These findings suggest ozone therapy may be a short-term treatment option, highlighting the need for further long-term studies.

Original Source(s)

The time-effect relationship of intra-articular ozone injection for knee osteoarthritis: a systematic review and meta-analysis

  • by Fengjiao Chen, Yufeng Tao, Jing Deng, Leyi Zhang, Lanlan Yu, Zhuoxi Yang, Yixuan Zhang, Chi Zhang

  • June 17, 2026

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