The association between maternal FT3/FT4 ratio in early pregnancy and adverse neonatal outcomes: a retrospective cohort study - Takeaways - MDSpire

Linking Maternal FT3/FT4 Ratio in Early Gestation to Negative Neonatal Outcomes: A Retrospective Cohort Analysis

  • By

  • Xiaoyu Chen

  • Fuyu Yang

  • Fanlong Meng

  • Lixin Li

  • Zhongyang Han

  • Jiayue Wang

  • Qingliang Shao

  • Shuang Li

  • Wei Sun

  • May 12, 2026

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  • 1

    The study analyzed 797 mother-infant pairs to assess the maternal FT3/FT4 ratio's impact on neonatal adverse outcomes.

  • 2

    Higher maternal FT3/FT4 ratios in early pregnancy were linked to increased risks of neonatal anemia, jaundice, and myocardial injury.

  • 3

    The association between FT3/FT4 ratio and neonatal outcomes followed a non-linear J-shaped pattern, with risks escalating beyond a specific threshold.

  • 4

    The risk of adverse outcomes was particularly significant in nulliparous women, mothers with normal BMI, and female neonates.

  • 5

    Elevated FT3/FT4 ratios may indicate maladaptive maternal metabolic responses, highlighting the need for new biomarkers in perinatal care.

Original Source(s)

The association between maternal FT3/FT4 ratio in early pregnancy and adverse neonatal outcomes: a retrospective cohort study

  • by Xiaoyu Chen, Fuyu Yang, Fanlong Meng, Lixin Li, Zhongyang Han, Jiayue Wang, Qingliang Shao, Shuang Li, Wei Sun

  • May 12, 2026

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