FT3 combined with the TyG index for risk stratification of mild cognitive impairment in euthyroid patients with type 2 diabetes - Takeaways - MDSpire

FT3 combined with the TyG index for risk stratification of mild cognitive impairment in euthyroid patients with type 2 diabetes

  • By

  • Yi Su

  • Lu Chen

  • Jing Huang

  • Haorui Lyu

  • Wei Feng

  • Jun Zhan

  • Yuyao Li

  • Zhanyi Ye

  • Xuan Liu

  • Changjiang Ying

  • June 22, 2026

  • 0 min

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  • 1

    Cognitive impairment is a significant complication of type 2 diabetes mellitus (T2DM), with patients having a higher risk of mild cognitive impairment (MCI).

  • 2

    Lower levels of free triiodothyronine (FT3) are independently associated with increased odds of MCI in euthyroid patients with T2DM.

  • 3

    The triglyceride-glucose (TyG) index shows a nonlinear association with MCI, with an inflection point at TyG = 9.24 indicating increased odds.

  • 4

    The combined FT3-TyG model demonstrates good discriminative ability for identifying individuals at higher risk of MCI in T2DM.

  • 5

    Physiological variations in FT3 and the TyG index may serve as accessible metabolic indicators for cognitive risk stratification in T2DM.

Original Source(s)

FT3 combined with the TyG index for risk stratification of mild cognitive impairment in euthyroid patients with type 2 diabetes

  • by Yi Su, Lu Chen, Jing Huang, Haorui Lyu, Wei Feng, Jun Zhan, Yuyao Li, Zhanyi Ye, Xuan Liu, Changjiang Ying

  • June 22, 2026

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