Tamsulosin Deprescribing for Lower Urinary Tract Symptoms in Older Men: A Randomized Clinical Trial - Takeaways - MDSpire

Tamsulosin Deprescribing for Lower Urinary Tract Symptoms in Older Men: A Randomized Clinical Trial

  • By

  • Scott R. Bauer

  • Stacey A. Kenfield

  • Akinyemi Oni-Orisan

  • Michael G. Shlipak

  • Kaiwei Lu

  • Natalie Rios

  • Robert Pearce

  • Joseph Harmon

  • Charles E. McCulloch

  • Liusheng Huang

  • Michael A. Steinman

  • Benjamin N. Breyer

  • July 6, 2026

  • 0 min

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  • 1

    One in 3 men will experience moderate-to-severe lower urinary tract symptoms (LUTS) in their lifetime, impacting health-related quality of life.

  • 2

    Tamsulosin, a commonly prescribed α-1 adrenergic receptor antagonist, is used by 1 in 5 men with LUTS, particularly among older men.

  • 3

    The efficacy of α-1 blockers like tamsulosin is modest, and many men who discontinue therapy do not require further treatment.

  • 4

    A series of N-of-1 trials were conducted to evaluate the efficacy of tamsulosin versus placebo in older men receiving chronic therapy.

  • 5

    The study aimed to identify older men who could benefit from stopping ineffective chronic tamsulosin therapy for LUTS.

Original Source(s)

Tamsulosin Deprescribing for Lower Urinary Tract Symptoms in Older Men: A Randomized Clinical Trial

  • by Scott R. Bauer, Stacey A. Kenfield, Akinyemi Oni-Orisan, Michael G. Shlipak, Kaiwei Lu, Natalie Rios, Robert Pearce, Joseph Harmon, Charles E. McCulloch, Liusheng Huang, Michael A. Steinman, Benjamin N. Breyer

  • July 6, 2026

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