Long term survival of patients with alpha-fetoprotein-positive hepatoid adenocarcinoma of the gallbladder: a case report and literature review - Takeaways - MDSpire

Long term survival of patients with alpha-fetoprotein-positive hepatoid adenocarcinoma of the gallbladder: a case report and literature review

  • By

  • Fangzhou Wang

  • Xiang Gao

  • Wei Gao

  • Jie Cai

  • Yamin Zheng

  • June 30, 2026

  • 0 min

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  • 1

    Hepatoid adenocarcinoma of the gallbladder is a rare and aggressive cancer variant associated with high alpha-fetoprotein production.

  • 2

    A 66-year-old male patient with AFP-positive HAC underwent radical resection and adjuvant transarterial chemoembolization.

  • 3

    Next-generation sequencing revealed a TP53 mutation and EGFR copy number amplification in the patient's tumor.

  • 4

    The patient's serum AFP levels normalized post-surgery, and he achieved 68 months of recurrence-free survival.

  • 5

    This case highlights the potential for improved outcomes in AFP-positive gallbladder HAC with aggressive surgical and adjunctive treatments.

Original Source(s)

Long term survival of patients with alpha-fetoprotein-positive hepatoid adenocarcinoma of the gallbladder: a case report and literature review

  • by Fangzhou Wang, Xiang Gao, Wei Gao, Jie Cai, Yamin Zheng

  • June 30, 2026

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