Genetics of supraventricular tachycardia: current evidence with a focus on translational relevance and personalized medicine

1

Supraventricular tachycardias (SVTs) are common arrhythmias that cause significant morbidity and healthcare utilization despite low mortality rates.
2

Genetic factors contribute to SVT susceptibility, with subtype-specific genetic architectures identified through familial studies and genome-wide association studies.
3

AVNRT shows familial clustering and polygenic susceptibility, while accessory pathway-mediated AVRT/WPW has a clearer genotype-to-substrate relationship.
4

Current genetic testing is most beneficial for syndromic and cardiomyopathy-associated SVT, where diagnosis can significantly alter patient management.
5

Advances in genetics and genomics are shifting SVT understanding towards inherited electrophysiologic diseases, emphasizing personalized medicine approaches.

1