PMOS-dementia link may reflect metabolic risks

Investigators identify insulin resistance and obesity as possible contributors to neurologic changes.

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Evidence linking polyendocrine metabolic ovarian syndrome (PMOS) to dementia was inconsistent across studies.
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A retrospective cohort found higher dementia prevalence and younger age at onset among patients with PMOS, whereas a prospective UK Biobank analysis found no significant association.
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Studies reported mild differences in executive function, attention, and memory, which were sometimes more closely associated with glycemic control and insulin resistance than PMOS status.
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Neuroimaging and biomarker studies identified brain and protein changes, but abnormalities were less pronounced in metabolically healthy patients with PMOS.
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The authors wrote that any PMOS–Alzheimer disease association is likely mediated by metabolic comorbidities, while limited longitudinal evidence prevents firm conclusions about long-term risk.

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