Explainable AI multiomics analysis reveals shared and divergent host responses in COVID-19 and influenza - Takeaways - MDSpire

Explainable AI multiomics analysis reveals shared and divergent host responses in COVID-19 and influenza

  • By

  • Yan Zhang

  • Lining Zhang

  • Zehong Zhang

  • Yuxi Lin

  • Zexu Jiang

  • Fulong Yu

  • January 27, 2026

  • 0 min

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  • 1

    COVID-19 severity is influenced by host genetics and immune regulation, with specific genes linked to susceptibility and severe outcomes.

  • 2

    Distinct pathophysiological features in COVID-19 include pulmonary microthrombosis and endotheliopathy, differing from influenza.

  • 3

    Comparative immune profiling reveals shared and unique responses in COVID-19 and influenza, with COVID-19 showing stronger antiviral programs.

  • 4

    The COVID-19 Multi-Omic Blood ATlas (COMBAT) identifies persistent activation of thrombo-inflammatory networks in severe cases.

  • 5

    This study integrates multi-omics data to clarify differences between COVID-19 and influenza, proposing host-directed therapeutic hypotheses.

Original Source(s)

Explainable AI multiomics analysis reveals shared and divergent host responses in COVID-19 and influenza

  • by Yan Zhang, Lining Zhang, Zehong Zhang, Yuxi Lin, Zexu Jiang, Fulong Yu

  • January 27, 2026

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