Case Report: Metastatic pancreatic ductal adenocarcinoma initially masked by multiple gastroduodenal ulcers with apparent endoscopic healing: a diagnostic pitfall - Takeaways - MDSpire

Case Report: Metastatic pancreatic ductal adenocarcinoma initially masked by multiple gastroduodenal ulcers with apparent endoscopic healing: a diagnostic pitfall

  • By

  • Conghua Song

  • Zhen Chen

  • Chaozhong Huang

  • Xiaomei Li

  • June 24, 2026

  • 0 min

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  • 1

    Pancreatic ductal adenocarcinoma (PDAC) often presents with nonspecific symptoms, complicating early diagnosis.

  • 2

    A 69-year-old man with multiple gastroduodenal ulcers showed apparent healing after acid suppression but had an unresolved etiology.

  • 3

    Despite endoscopic improvement, rising CA19-9 levels prompted further imaging, revealing metastatic PDAC.

  • 4

    Histopathological examination of ulcers initially showed chronic inflammation without malignancy, complicating diagnosis.

  • 5

    This case illustrates the need for thorough investigation of unexplained ulcerative disease, even with endoscopic resolution.

Original Source(s)

Case Report: Metastatic pancreatic ductal adenocarcinoma initially masked by multiple gastroduodenal ulcers with apparent endoscopic healing: a diagnostic pitfall

  • by Conghua Song, Zhen Chen, Chaozhong Huang, Xiaomei Li

  • June 24, 2026

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