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A Bibliometric Examination of the Global Research Trends Surrounding Tertiary Lymphoid Structures in Autoimmune Disorders

  • By

  • Jiaqi Wang

  • Yiyuanzi Zhao

  • Xixuan Chen

  • Tianshu Dong

  • Zhiyi Feng

  • Zhongmian Zhang

  • Zhihong Li

  • July 14, 2026

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  • 1

    Tertiary lymphoid structures (TLSs) are significant in chronic inflammation and autoimmunity, serving as local immune niches.

  • 2

    The study analyzed 479 publications on TLSs in autoimmune diseases from 2006 to 2025, revealing an upward trend in research output.

  • 3

    Key autoimmune diseases associated with TLS research include rheumatoid arthritis, Sjögren’s syndrome, systemic lupus erythematosus, and myasthenia gravis.

  • 4

    Research has evolved from structural recognition of TLSs to understanding their functional roles and implications in disease stratification.

  • 5

    Recent advancements in TLS research focus on T-cell interactions, stromal remodeling, and single-cell/spatial omics technologies.

Original Source(s)

Global research landscape and emerging trends of tertiary lymphoid structures in autoimmune diseases: a bibliometric analysis

  • by Jiaqi Wang, Yiyuanzi Zhao, Xixuan Chen, Tianshu Dong, Zhiyi Feng, Zhongmian Zhang, Zhihong Li

  • July 14, 2026

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