Children with autism spectrum disorder (ASD) exhibited higher urinary concentrations of microbially derived metabolites compared to typically developing controls.
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The study achieved 90% sensitivity and 100% specificity in classifying children with ASD based on elevated metabolite levels.
3
Researchers identified over 600 metabolites differing between groups, with 23 of 24 selected metabolites significantly elevated in children with ASD.
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The MDM System developed in the study assigned scores based on elevated metabolites, with children with ASD averaging a score of 3.3.
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The study was a pilot and highlighted the need for replication in an independent cohort due to its limitations and exclusions.
