Calcium-Sensing Receptor Regulation of Gastrointestinal Hormone Secretion - Takeaways - MDSpire

Calcium-Sensing Receptor Regulation of Gastrointestinal Hormone Secretion

  • By

  • Javad Anjom-Shoae

  • Simon Veedfald

  • Arthur D Conigrave

  • Michael Horowitz

  • Christine Feinle-Bisset

  • December 1, 2025

  • 0 min

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  • 1

    Dietary nutrients activate chemoreceptors in the gastrointestinal tract, stimulating the release of over 20 gut hormones essential for digestion and energy regulation.

  • 2

    The calcium-sensing receptor (CaSR) is crucial for sensing extracellular calcium and mediates gut hormone secretion in response to aromatic amino acids.

  • 3

    L-tryptophan and L-phenylalanine stimulate the secretion of gut hormones like CCK, GLP-1, and PYY, with their effects enhanced by extracellular calcium.

  • 4

    In humans, both calcium and amino acids can increase gut hormone levels, leading to reduced energy intake and improved postprandial glycemia.

  • 5

    The findings suggest potential nutrient-based strategies for managing obesity and type 2 diabetes through modulation of gut hormone release.

Original Source(s)

Calcium-Sensing Receptor Regulation of Gastrointestinal Hormone Secretion

  • by Javad Anjom-Shoae, Simon Veedfald, Arthur D Conigrave, Michael Horowitz, Christine Feinle-Bisset

  • December 1, 2025

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