Antibiotic use and immune-related adverse events in patients treated with immune checkpoint inhibitors: analysis of the FAERS database

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Antibiotic use in patients treated with immune checkpoint inhibitors (ICIs) is associated with a higher frequency of immune-related adverse events (irAEs).
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Patients receiving antibiotics during ICI therapy reported irAEs with a median onset time of 31 days, shorter than the 42 days for those not on antibiotics.
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The strongest associations with increased irAEs were found in patients treated with fluoroquinolones, sulfonamides, penicillin, and PD-L1 inhibitors.
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The study utilized data from the FAERS database, analyzing 155,157 patients, with 9,518 (6.1%) receiving antibiotic therapy.
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Findings suggest a need for prospective studies to explore the impact of antibiotics on irAEs and the gut microbiota during ICI treatment.

Frontiers In Immunology

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