Amino acid-based formula with synbiotics for cow's milk protein allergy: a real-world study of symptom evolution and quality-of-life outcomes

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The study investigated symptom progression in infants with cow's milk protein allergy using an amino acid-based formula with synbiotics.
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A total of 71 infants completed the 28-day observation, showing a significant decrease in cow’s milk allergy symptom scores.
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Mean CoMiSS scores decreased from 10.1 at baseline to 3.5 on Day 28, indicating improvement in allergy symptoms.
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Caregiver-reported outcomes, including gastrointestinal symptoms and quality of life, also improved over the 28-day period.
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One-year follow-up data were available for 56 children, providing descriptive insights into growth and health resource use.

Frontiers In Pediatrics

by Sebastián Ramiro Soria, Pablo Malagrino, Estefanía Sacconi, Graciela Martin, Nicolás Rovati, Verónica Plante, Florencia Grisel Ursino, María Florencia Biasoli, Natalia Alejandra Petriz, Paula Micone, Eugenia Maciero, Norberto Giglio
July 6, 2026

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