Role of the frontal aslant tract in language preservation and recovery after surgery: a multicenter analysis of patients with left frontal glioma

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The study evaluated the impact of the frontal aslant tract (FAT) on language function in patients undergoing surgery for left frontal gliomas.
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A total of 51 patients were recruited, with maximal tumor resection achieved in 58.8% of cases, and 56.9% experienced postoperative language worsening.
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Surgical manipulation of the FAT was linked to language impairment, particularly the volume of fibers resected and the specific FAT segment involved.
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Resection of the middle segment of the FAT was associated with immediate language worsening and poor long-term outcomes.
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A FAT resection volume of at least 0.5 cm3 was identified as a significant predictor of persistent language deficits post-surgery.

Frontiers In Neurology

by L. F. Salvati, R. De Marco, F. Balletti, A. Morello, A. Gatto, A. Leocata, P. Fiaschi, S. Caneva, B. Cagetti, M. Truffelli, F. Bruno, A. Tabano, G. Zona, F. Cofano, R. Rudà, D. Garbossa, A. Bianconi
July 3, 2026

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