Transcranial magnetic stimulation-based evaluation of exercise training-induced changes in TMS-derived neurophysiological markers and motor performance in healthy adults: a systematic review and meta-analysis of RCTs - Takeaways - MDSpire

Transcranial magnetic stimulation-based evaluation of exercise training-induced changes in TMS-derived neurophysiological markers and motor performance in healthy adults: a systematic review and meta-analysis of RCTs

  • By

  • Yili Gao

  • Ziwen Zhen

  • Juanjuan Hu

  • June 25, 2026

  • 0 min

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  • 1

    This systematic review evaluated the effects of exercise training on TMS-derived neurophysiological markers and motor performance in healthy adults.

  • 2

    Twelve randomized controlled trials were included, with a total of 137 exercise and 136 control participants for TMS-derived markers.

  • 3

    Meta-analysis revealed significant pooled effects for TMS-derived markers (Hedges' g = 0.53) and motor performance (Hedges' g = 0.58).

  • 4

    Moderate heterogeneity was observed for both TMS-derived markers and motor performance outcomes, with prediction intervals crossing zero.

  • 5

    The study concluded that more standardized, adequately powered RCTs are needed to confirm the effects of exercise training on neurophysiological markers.

Original Source(s)

Transcranial magnetic stimulation-based evaluation of exercise training-induced changes in TMS-derived neurophysiological markers and motor performance in healthy adults: a systematic review and meta-analysis of RCTs

  • by Yili Gao, Ziwen Zhen, Juanjuan Hu

  • June 25, 2026

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