Associations of Serum Testosterone and SHBG With Incident Fractures in Middle-aged to Older Men - Takeaways - MDSpire

Associations of Serum Testosterone and SHBG With Incident Fractures in Middle-aged to Older Men

  • By

  • Louise Grahnemo

  • Ross J Marriott

  • Kevin Murray

  • Lauren T Tyack

  • Maria Nethander

  • Alvin M Matsumoto

  • Eric S Orwoll

  • Dirk Vanderschueren

  • Bu B Yeap

  • Claes Ohlsson

  • October 7, 2024

  • 0 min

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  • 1

    Lower serum SHBG levels are strongly associated with a reduced risk of hip and forearm fractures in middle-aged and older men.

  • 2

    Circulating testosterone has a nonlinear association with hip fractures, showing the lowest risk in the second quintile.

  • 3

    The relationship between circulating testosterone and fracture risk is inconsistent and affected by adjustments for SHBG.

  • 4

    Both total testosterone and SHBG should be evaluated to understand their relationship with fracture risk in older men.

  • 5

    The UK Biobank study included over 205,000 participants, providing a robust dataset for analyzing fracture risk factors.

Original Source(s)

Associations of Serum Testosterone and SHBG With Incident Fractures in Middle-aged to Older Men

  • by Louise Grahnemo, Ross J Marriott, Kevin Murray, Lauren T Tyack, Maria Nethander, Alvin M Matsumoto, Eric S Orwoll, Dirk Vanderschueren, Bu B Yeap, Claes Ohlsson

  • October 7, 2024

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