Evidence-based interventions to restore or improve female fertility in women aged 30–42 years: a systematic review by etiology and evidence level - Takeaways - MDSpire

Evidence-based interventions to restore or improve female fertility in women aged 30–42 years: a systematic review by etiology and evidence level

  • By

  • Maria Jimena Barroso Alverde

  • Sion Yu

  • Daniel Pascal Pontón

  • Denise Niza Benardete Harari

  • José Elias Tesone Lasman

  • June 9, 2026

  • 0 min

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  • 1

    Female infertility affects one in six couples globally, with significant impact on women aged 30–42 years due to various etiologies.

  • 2

    The systematic review synthesized evidence from 21 studies on interventions aimed at improving fertility outcomes in women aged 30–42 years.

  • 3

    Interventions such as myo-inositol, clomiphene with sildenafil, and structured stress management showed improved pregnancy outcomes.

  • 4

    Moderate-certainty evidence supports live-birth effects, but limitations include small sample sizes and inconsistent safety reporting.

  • 5

    Future research should focus on live birth outcomes, standardized core outcomes, and comprehensive safety reporting in fertility interventions.

Original Source(s)

Evidence-based interventions to restore or improve female fertility in women aged 30–42 years: a systematic review by etiology and evidence level

  • by Maria Jimena Barroso Alverde, Sion Yu, Daniel Pascal Pontón, Denise Niza Benardete Harari, José Elias Tesone Lasman

  • June 9, 2026

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