Depressive symptoms and risk of incident activities of daily living disability among older adults with symptomatic arthritis - Takeaways - MDSpire
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Association of Depressive Symptoms with the Onset of Daily Living Disability in Older Adults Suffering from Symptomatic Arthritis

  • By

  • Jingxuan Cui

  • Jian Kang

  • Shuaiyu Li

  • Linru Zeng

  • Chen Li

  • June 1, 2026

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  • 1

    Depressive symptoms significantly increase the risk of activities of daily living (ADL) disability in older adults with symptomatic arthritis.

  • 2

    Each 1-point increase in CES-D score correlates with a 7% higher risk of ADL disability in ELSA and a 10% higher risk in HRS.

  • 3

    Participants with depression have a substantially elevated risk of ADL disability, with adjusted HRs of 1.26 in ELSA and 1.49 in HRS.

  • 4

    Physical activity partially mediates the association between depressive symptoms and ADL disability, accounting for about 9.1% in ELSA and 5.0% in HRS.

  • 5

    The study highlights the need for integrated mental health and lifestyle interventions to reduce functional decline in older adults with arthritis.

Original Source(s)

Depressive symptoms and risk of incident activities of daily living disability among older adults with symptomatic arthritis

  • by Jingxuan Cui, Jian Kang, Shuaiyu Li, Linru Zeng, Chen Li

  • June 1, 2026

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