Mapping Lipid Rewiring During Drug-Induced Cell Death
Fiber-based imaging platform reveals nanoscale heterogeneity and drug-specific metabolic fingerprints in cancer cells
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A novel mass spectrometry imaging platform visualizes lipid metabolism at the single-cell level with ~800 nm resolution.
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The system allows researchers to investigate lipid reorganization during drug-induced apoptosis in HeLa and HepG2 cells.
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The study found dose- and time-dependent lipid remodeling, with structural phospholipids declining and energy-storage lipids mobilizing.
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Distinct lipid fingerprints were observed for different drugs, indicating varied mechanisms of action and cellular variability.
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The platform also successfully imaged lipid distributions in mouse brain tissue, suggesting broader applications in drug development.
