Intragraft donor-specific antibodies reflect histologic heterogeneity in kidney allografts with concurrent serum DSA - Takeaways - MDSpire

Intragraft donor-specific antibodies reflect histologic heterogeneity in kidney allografts with concurrent serum DSA

  • By

  • Hyunjae Lee

  • Eun Youn Roh

  • Tae-Shin Kim

  • Yu Jung Choi

  • Inseong Oh

  • Hajeong Lee

  • Sang Il Min

  • Chang Wook Jeong

  • Hee Gyung Kang

  • Jongwon Ha

  • Kyung Chul Moon

  • Eun Young Song

  • June 23, 2026

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  • 1

    Intragraft donor-specific antibodies (gDSA) were analyzed in kidney biopsies from recipients with concurrent weak to moderate circulating donor-specific antibodies (sDSA).

  • 2

    The prevalence of gDSA varied significantly across histologic diagnoses, with the highest positivity in C4d-only lesions and active antibody-mediated rejection (aABMR).

  • 3

    The gDSA positive rate in aABMR was significantly higher than in the no-rejection group, indicating a strong association with histologic findings.

  • 4

    The mean fluorescence intensity (MFI) sum of gDSA was significantly higher in aABMR and related lesions compared to other histologic groups.

  • 5

    The study suggests that gDSA may provide additional immunologic context for understanding histologic variability in kidney transplant recipients with sDSA.

Original Source(s)

Intragraft donor-specific antibodies reflect histologic heterogeneity in kidney allografts with concurrent serum DSA

  • by Hyunjae Lee, Eun Youn Roh, Tae-Shin Kim, Yu Jung Choi, Inseong Oh, Hajeong Lee, Sang Il Min, Chang Wook Jeong, Hee Gyung Kang, Jongwon Ha, Kyung Chul Moon, Eun Young Song

  • June 23, 2026

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