Association of the neonatal sequential organ failure assessment score with neurological outcomes in infants diagnosed with hypoxic-ischemic encephalopathy - Takeaways - MDSpire

Association of the neonatal sequential organ failure assessment score with neurological outcomes in infants diagnosed with hypoxic-ischemic encephalopathy

  • By

  • Kaitlyn Lagnese

  • Shamil Sheth

  • Shannon Vice

  • Dhanashree Rajderkar

  • Juan C. Roig

  • Michael Weiss

  • James L. Wynn

  • May 29, 2026

  • 0 min

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  • 1

    The study evaluated the relationship between neonatal sequential organ failure assessment scores and neurological outcomes in infants with hypoxic-ischemic encephalopathy.

  • 2

    Among 122 infants with HIE, 29.5% had abnormal MRI results, and 34.8% met criteria for neurodevelopmental impairment by 12 months.

  • 3

    Models using laboratory values and maximum nSOFA scores showed good predictive accuracy for abnormal MRI and neurodevelopmental impairment.

  • 4

    Early physiologic and laboratory measures were associated with MRI-defined injury and neurodevelopmental outcomes in infants treated with therapeutic hypothermia.

  • 5

    The findings suggest that integrating early organ dysfunction measures may enhance risk stratification and prognostic assessment in HIE patients.

Original Source(s)

Association of the neonatal sequential organ failure assessment score with neurological outcomes in infants diagnosed with hypoxic-ischemic encephalopathy

  • by Kaitlyn Lagnese, Shamil Sheth, Shannon Vice, Dhanashree Rajderkar, Juan C. Roig, Michael Weiss, James L. Wynn

  • May 29, 2026

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