Prenatal immune activation and adult Poly(I:C) re-challenge promote neuroimmune priming and AD-related behavioural, cellular and molecular alterations in wild-type mice - Takeaways - MDSpire

Prenatal immune activation and adult Poly(I:C) re-challenge promote neuroimmune priming and AD-related behavioural, cellular and molecular alterations in wild-type mice

  • By

  • Giacomo Giacovazzo

  • Valentina Latina

  • Zuleyha Nihan Yurtsever

  • Iliana Piccolino

  • Filomena Iannuzzi

  • Paola Bossù

  • Giuseppina Amadoro

  • Roberto Coccurello

  • July 8, 2026

  • 0 min

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  • 1

    Prenatal immune stimulation followed by adult re-exposure to Poly(I:C) induces cognitive and social deficits in wild-type mice.

  • 2

    Poly(I:C)-exposed mice show increased amyloidogenic APP processing and tau dysregulation, indicating neurodegenerative changes.

  • 3

    Behavioral abnormalities in Poly(I:C)-exposed mice include impaired recognition memory and reduced social interaction.

  • 4

    Microglial activation and synaptic alterations were observed in the hippocampus of Poly(I:C)-exposed mice.

  • 5

    The study suggests that repeated immune activation may contribute to neurodegenerative phenotypes relevant to Alzheimer's disease.

Original Source(s)

Prenatal immune activation and adult Poly(I:C) re-challenge promote neuroimmune priming and AD-related behavioural, cellular and molecular alterations in wild-type mice

  • by Giacomo Giacovazzo, Valentina Latina, Zuleyha Nihan Yurtsever, Iliana Piccolino, Filomena Iannuzzi, Paola Bossù, Giuseppina Amadoro, Roberto Coccurello

  • July 8, 2026

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