Effects of exercise training on nitric oxide metabolites in heart failure with reduced or preserved ejection fraction: a secondary analysis of the SMARTEX-HF and OptimEx-Clin trials - Takeaways - MDSpire

Effects of exercise training on nitric oxide metabolites in heart failure with reduced or preserved ejection fraction: a secondary analysis of the SMARTEX-HF and OptimEx-Clin trials

  • By

  • Sophia Marie-Theres Dinges

  • Edzard Schwedhelm

  • Julia Schoenfeld

  • Andreas B Gevaert

  • Ephraim B Winzer

  • Bernhard Haller

  • Flavia Baldassarri

  • Axel Pressler

  • André Duvinage

  • Rainer Böger

  • Axel Linke

  • Volker Adams

  • Burkert Pieske

  • Frank Edelmann

  • Håvard Dalen

  • Torstein Hole

  • Alf Inge Larsen

  • Patrick Feiereisen

  • Trine Karlsen

  • Eva Prescott

  • Øyvind Ellingsen

  • Emeline M Van Craenenbroeck

  • Martin Halle

  • Stephan Mueller

  • March 14, 2025

  • 0 min

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  • 1

    Exercise training affects the nitric oxide pathway, which is crucial in the pathophysiology of endothelial dysfunction in heart failure.

  • 2

    Higher baseline levels of homoarginine and asymmetric dimethylarginine were found in patients with heart failure with reduced ejection fraction compared to preserved ejection fraction.

  • 3

    No significant changes in nitric oxide metabolite plasma levels were observed after 3 months of exercise training across different exercise modes.

  • 4

    Baseline nitric oxide metabolite profiles were linked to heart failure severity, with unfavorable profiles associated with lower exercise capacity.

  • 5

    Microvascular endothelial dysfunction was more prevalent in heart failure with reduced ejection fraction than in preserved ejection fraction.

Original Source(s)

Effects of exercise training on nitric oxide metabolites in heart failure with reduced or preserved ejection fraction: a secondary analysis of the SMARTEX-HF and OptimEx-Clin trials

  • by Sophia Marie-Theres Dinges, Edzard Schwedhelm, Julia Schoenfeld, Andreas B Gevaert, Ephraim B Winzer, Bernhard Haller, Flavia Baldassarri, Axel Pressler, André Duvinage, Rainer Böger, Axel Linke, Volker Adams, Burkert Pieske, Frank Edelmann, Håvard Dalen, Torstein Hole, Alf Inge Larsen, Patrick Feiereisen, Trine Karlsen, Eva Prescott, Øyvind Ellingsen, Emeline M Van Craenenbroeck, Martin Halle, Stephan Mueller

  • March 14, 2025

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