Advancing Precision Cardio-Oncology in Breast Cancer Radiotherapy

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Radiotherapy is essential for breast cancer treatment, reducing recurrence and mortality while improving long-term survival.
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Left-sided radiotherapy is linked to a higher risk of ischemic heart disease compared to right-sided treatment, particularly in women with multiple cardiovascular risk factors.
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A new cardiovascular risk burden score considers factors like age, obesity, and hypertension to assess patient vulnerability to radiation-induced heart disease.
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Individualized treatment planning should focus on absolute cardiovascular risk rather than solely on radiotherapy laterality.
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Future research should combine registry follow-up with detailed dosimetry and validated cardiovascular risk assessments to improve patient outcomes.

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