Adjuvant-driven epitope hierarchy correlates with the protective efficacy of FimA vaccine against Klebsiella pneumoniae - Takeaways - MDSpire
Coming Soon: Introducing MDSpire News. Learn more
Conexiant’s news site is now MDSpire News. Learn more

Influence of Adjuvants on the Hierarchical Structure of FimA Epitopes and Its Impact on Vaccine Efficacy Against Klebsiella pneumoniae

  • By

  • Guangyang Ming

  • Longlong Chen

  • Pengju Yan

  • Xiaoqiong Wang

  • Zhifu Chen

  • Qiang Gou

  • Yue Yuan

  • Jiayi Chen

  • Haiming Jing

  • Ping Luo

  • Quanming Zou

  • Jinyong Zhang

  • Zhiyong Liu

  • Renjian Hu

  • Zhuo Zhao

  • June 22, 2026

Share

  • 1

    Hypervirulent Klebsiella pneumoniae (hvKP) variants are urgent multidrug-resistant threats with no licensed vaccine available.

  • 2

    FimA is a promising vaccine target due to its essential role in Klebsiella pneumoniae mucosal colonization.

  • 3

    Different adjuvants significantly influence the hierarchy of immunodominant B-cell epitopes of FimA and protective immunity.

  • 4

    AddaS03-adjuvanted vaccines showed 100% survival in mice, while AddaVax resulted in only 40% survival after lethal hvKP challenge.

  • 5

    Rational adjuvant selection may enhance FimA-induced immune responses, potentially improving vaccine efficacy against Klebsiella pneumoniae.

Original Source(s)

Adjuvant-driven epitope hierarchy correlates with the protective efficacy of FimA vaccine against Klebsiella pneumoniae

  • by Guangyang Ming, Longlong Chen, Pengju Yan, Xiaoqiong Wang, Zhifu Chen, Qiang Gou, Yue Yuan, Jiayi Chen, Haiming Jing, Ping Luo, Quanming Zou, Jinyong Zhang, Zhiyong Liu, Renjian Hu, Zhuo Zhao

  • June 22, 2026

Related Content

Hybrid immunity from bivalent vaccination and prior infection enhances humoral and innate protection against Omicron XBB.1.16 and EG.5.1.1 variants in Japan

Engagement Trends in Online Vaccine Content: Longitudinal YouTube Study

A Global Perspective of Childhood Vaccinations: Past, Present, and Future—From Smallpox to mRNA