Adjuvant-driven epitope hierarchy correlates with the protective efficacy of FimA vaccine against Klebsiella pneumoniae - Takeaways - MDSpire

Adjuvant-driven epitope hierarchy correlates with the protective efficacy of FimA vaccine against Klebsiella pneumoniae

  • By

  • Guangyang Ming

  • Longlong Chen

  • Pengju Yan

  • Xiaoqiong Wang

  • Zhifu Chen

  • Qiang Gou

  • Yue Yuan

  • Jiayi Chen

  • Haiming Jing

  • Ping Luo

  • Quanming Zou

  • Jinyong Zhang

  • Zhiyong Liu

  • Renjian Hu

  • Zhuo Zhao

  • June 22, 2026

  • 0 min

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  • 1

    Hypervirulent Klebsiella pneumoniae (hvKP) variants are urgent multidrug-resistant threats with no licensed vaccine available.

  • 2

    FimA is a promising vaccine target due to its essential role in Klebsiella pneumoniae mucosal colonization.

  • 3

    Different adjuvants significantly influence the hierarchy of immunodominant B-cell epitopes of FimA and protective immunity.

  • 4

    AddaS03-adjuvanted vaccines showed 100% survival in mice, while AddaVax resulted in only 40% survival after lethal hvKP challenge.

  • 5

    Rational adjuvant selection may enhance FimA-induced immune responses, potentially improving vaccine efficacy against Klebsiella pneumoniae.

Original Source(s)

Adjuvant-driven epitope hierarchy correlates with the protective efficacy of FimA vaccine against Klebsiella pneumoniae

  • by Guangyang Ming, Longlong Chen, Pengju Yan, Xiaoqiong Wang, Zhifu Chen, Qiang Gou, Yue Yuan, Jiayi Chen, Haiming Jing, Ping Luo, Quanming Zou, Jinyong Zhang, Zhiyong Liu, Renjian Hu, Zhuo Zhao

  • June 22, 2026

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