Exercise in regional breast cancer with neoadjuvant anthracycline-based chemotherapy with immune checkpoint-inhibition: study protocol for a prospective randomised controlled trial - Takeaways - MDSpire

Exercise in regional breast cancer with neoadjuvant anthracycline-based chemotherapy with immune checkpoint-inhibition: study protocol for a prospective randomised controlled trial

  • By

  • Elena Murr

  • Sabine Grill

  • Marion Kiechle

  • Anne Kraemer

  • Bernadine Madl

  • Simon Glowka

  • Bernhard Haller

  • Caterina Fiorentini

  • Emmanuel Adjej

  • Mark J Haykowsky

  • Martin Halle

  • Simon Wernhart

  • June 5, 2026

  • 0 min

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  • 1

    The ExACT-ICI trial investigates the impact of exercise training during neoadjuvant chemotherapy in triple negative breast cancer patients.

  • 2

    Participants will be randomized into exercise training or usual care groups, with exercise monitored via smartwatches.

  • 3

    The primary outcome is the change in VO2peak from baseline to 24 weeks, with secondary outcomes including physical function and quality of life.

  • 4

    This study aims to address the effectiveness of exercise interventions during combined immunochemotherapy, a previously unexplored area.

  • 5

    The trial will last approximately 52 weeks, with recruitment expected to continue until December 2027.

Original Source(s)

Exercise in regional breast cancer with neoadjuvant anthracycline-based chemotherapy with immune checkpoint-inhibition: study protocol for a prospective randomised controlled trial

  • by Elena Murr, Sabine Grill, Marion Kiechle, Anne Kraemer, Bernadine Madl, Simon Glowka, Bernhard Haller, Caterina Fiorentini, Emmanuel Adjej, Mark J Haykowsky, Martin Halle, Simon Wernhart

  • June 5, 2026

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