Association of LVOT Gradient and LA Strain with Cardiac Events in Pediatric HCM - Takeaways - MDSpire

Association of LVOT Gradient and LA Strain with Cardiac Events in Pediatric HCM

  • By

  • Addison Gearhart

  • Sonia F. Epstein

  • Kimberlee Gauvreau

  • Alessandra Ferraro

  • Christina M. Mangano

  • Ingrid Roth

  • David Harrild

  • Steven D. Colan

  • Ming Hui Chen

  • June 18, 2026

  • 0 min

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  • 1

    Hypertrophic cardiomyopathy (HCM) in children can lead to left ventricular outflow tract (LVOT) obstruction, defined as a gradient ≥ 30 mm Hg.

  • 2

    Exercise-induced LVOT gradients and left atrial (LA) strain are important indicators of cardiac events in pediatric HCM patients.

  • 3

    The study analyzed data from children with HCM who underwent exercise stress echocardiography at Boston Children’s Hospital.

  • 4

    Patients were categorized into three groups based on resting and exercise-induced LVOT gradients to assess their risk of cardiac events.

  • 5

    A composite cardiac endpoint was used to evaluate significant events, including heart failure, syncope, and HCM-related death.

Original Source(s)

Association of LVOT Gradient and LA Strain with Cardiac Events in Pediatric HCM

  • by Addison Gearhart, Sonia F. Epstein, Kimberlee Gauvreau, Alessandra Ferraro, Christina M. Mangano, Ingrid Roth, David Harrild, Steven D. Colan, Ming Hui Chen

  • June 18, 2026

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