The PROMISE Initiative: Developing Reliable Living Evidence for Pediatric Medication Safety through the Trial Bank Project - Takeaways - MDSpire

The PROMISE Initiative: Developing Reliable Living Evidence for Pediatric Medication Safety through the Trial Bank Project

  • By

  • Chang Xu

  • Suhail A. Doi

  • Sunita Vohra

  • Luis Furuya-Kanamori

  • Yingxia Wang

  • Lijun Tang

  • Yuan Tian

  • Shiqi Fan

  • Zhen Peng

  • Evan Mayo-Wilson

  • Lifeng Lin

  • Haitao Chu

  • M. Hassan Murad

  • Tianqi Yu

  • Sheyu Li

  • Yaolong Chen

  • Su Golder

  • Yoon Loke

  • Justin Clark

  • Paul Glasziou

  • Liang Du

  • Houwen Lin

  • Zhichun Gu

  • February 21, 2026

  • 0 min

Share

  • 1

    The PROMISE initiative aims to enhance pediatric medication safety by developing a Trial Bank for reliable evidence on medication-related harms.

  • 2

    Medication-related harms significantly impact children, contributing to millions of adverse events and deaths globally each year.

  • 3

    Current randomized controlled trials often lack robust data on medication harms due to low event rates and limited sample sizes.

  • 4

    Advancements in artificial intelligence can facilitate the creation of a continuously updated Trial Bank for efficient evidence synthesis.

  • 5

    The project includes systematic literature searches, data extraction, and standardization to improve the understanding of pediatric medication safety.

Original Source(s)

The PROMISE Initiative: Developing Reliable Living Evidence for Pediatric Medication Safety through the Trial Bank Project

  • by Chang Xu, Suhail A. Doi, Sunita Vohra, Luis Furuya-Kanamori, Yingxia Wang, Lijun Tang, Yuan Tian, Shiqi Fan, Zhen Peng, Evan Mayo-Wilson, Lifeng Lin, Haitao Chu, M. Hassan Murad, Tianqi Yu, Sheyu Li, Yaolong Chen, Su Golder, Yoon Loke, Justin Clark, Paul Glasziou, Liang Du, Houwen Lin, Zhichun Gu

  • February 21, 2026

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