Caution Against Overinterpretation of Results in the FENETRE Trial - Takeaways - MDSpire

Caution Against Overinterpretation of Results in the FENETRE Trial

  • By

  • Isaiah J. Miller

  • Sally S. Ong

  • June 15, 2026

  • 0 min

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  • 1

    Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss, affecting over 8 million people globally in 2021.

  • 2

    The FENETRE trial examined community optometrist-led monitoring of quiescent neovascular AMD, enrolling 704 adults across 17 NHS hospitals and 60 community practices.

  • 3

    Community optometrists had a false-negative rate of 3.8%, while hospital monitoring had a rate of 7.8%, meeting the noninferiority margin.

  • 4

    Optometrists in the FENETRE trial underwent a dedicated training program, emphasizing the need for specialized training for safe monitoring of AMD.

  • 5

    The study's results should not be generalized to other health systems due to differences in optometrist credentialing and training pathways.

Original Source(s)

Caution Against Overinterpretation of Results in the FENETRE Trial

  • by Isaiah J. Miller, Sally S. Ong

  • June 15, 2026

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