Efficacy of methimazole combined with traditional Chinese medicine in the treatment of Graves’ disease: a systematic review and network meta-analysis

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A systematic review evaluated the effectiveness of Traditional Chinese Medicine (TCM) combined with Methimazole (MMI) in managing Graves' Disease.
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The network meta-analysis included 15 RCTs with 1,317 patients, showing TCM plus MMI may improve thyroid function and reduce autoantibodies.
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Modified Huagan Decoction (MHD) + MMI ranked highest for reducing FT3, while Modified Xiaoyao Powder (MXYP) + MMI ranked highest for FT4.
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Xiaoyao Powder (XYP) + MMI was ranked first for regulating TSH, and Huotan Jiangni Formula (HJF) + MMI ranked highest for lowering TPOAb.
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Adverse events were reported descriptively due to incomplete and heterogeneous reporting across the included RCTs.

Frontiers In Endocrinology

by Tiantian Kuan, Wenzhi Tian, Peiran Wang, Dong Chen, Chenchen Hu, Peng Li, Xi Su
July 14, 2026

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