Case Report: Bilateral Wilms tumor with TP53 mutation: a case-based review of clinical challenges - Takeaways - MDSpire

Case Report: Bilateral Wilms tumor with TP53 mutation: a case-based review of clinical challenges

  • By

  • Xin Zhang

  • Qianqian Cheng

  • Pinxiu Wang

  • Zhen Tan

  • May 21, 2026

  • 0 min

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  • 1

    Bilateral Wilms tumor (BWT) represents 5%-7% of Wilms tumors and has a poorer prognosis compared to unilateral cases.

  • 2

    Standard treatment for BWT includes neoadjuvant chemotherapy and nephron-sparing surgery to maintain renal function.

  • 3

    Patients with TP53 mutations often show intrinsic chemoresistance, complicating management and leading to poor outcomes.

  • 4

    A case of a 3-year-old girl with BWT and TP53 mutation demonstrated rapid disease progression despite guideline-concordant treatment.

  • 5

    Current treatment strategies need to evolve to address the challenges posed by high-risk molecular subtypes like TP53 mutations.

Original Source(s)

Case Report: Bilateral Wilms tumor with TP53 mutation: a case-based review of clinical challenges

  • by Xin Zhang, Qianqian Cheng, Pinxiu Wang, Zhen Tan

  • May 21, 2026

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