Morphological characteristics of acquired corneal sub-epithelium hypertrophy: a case series - Takeaways - MDSpire

Morphological characteristics of acquired corneal sub-epithelium hypertrophy: a case series

  • By

  • Qiaoyu Li

  • Yunfan Zhang

  • Haimiao Lin

  • Zhaoxiang Lu

  • Wenyu Wu

  • Yun Feng

  • June 17, 2026

  • 0 min

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  • 1

    Acquired Corneal Subepithelial Hypertrophy (ACSH) is a rare corneal opacity often misdiagnosed due to non-specific slit-lamp findings.

  • 2

    The study analyzed 11 patients with ACSH using AS-OCT and histopathological evaluations to characterize its morphological features.

  • 3

    ACSH was categorized into three subtypes: paracentral patchy opacification, peripheral sectorial nodules, and central diffuse mass.

  • 4

    Superficial keratectomy effectively restored corneal clarity in patients without recurrence during follow-up.

  • 5

    AS-OCT is a reliable tool for diagnosing ACSH, differentiating it from other corneal opacities, and informing clinical management.

Original Source(s)

Morphological characteristics of acquired corneal sub-epithelium hypertrophy: a case series

  • by Qiaoyu Li, Yunfan Zhang, Haimiao Lin, Zhaoxiang Lu, Wenyu Wu, Yun Feng

  • June 17, 2026

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