Breast Cancer Is Increased in Women With Primary Ovarian Insufficiency

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Women with primary ovarian insufficiency (POI) have a significantly increased risk of breast cancer, with an odds ratio of 2.20.
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The study identified a nominally significant increase in ovarian cancer risk among women with POI.
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Second-degree relatives of women with POI also showed increased risks for breast and colon cancer.
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First, second, and third-degree relatives of women with POI had elevated risks for prostate cancer.
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Common genetic variants associated with POI may also contribute to the risk of reproductive cancers.

The Journal Of Clinical Endocrinology & Metabolism

by Kristina Allen-Brady, Barry Moore, Lauren E Verrilli, Margaret A Alvord, Marina Kern, Nicola Camp, Kristen Kelley, Joseph Letourneau, Lisa Cannon-Albright, Mark Yandell, Erica B Johnstone, Corrine K Welt
July 12, 2024

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