How Quickly Are Patients Reaching Quadruple HFrEF Therapy?

Delays in initiating guideline-directed quadruple therapy may increase early clinical risk in heart failure with reduced ejection fraction.

1

Less than 25% of veterans with newly diagnosed HFrEF achieved quadruple therapy during a median follow-up of 2.9 years.
2

The median time to achieve quadruple therapy was over 6 months, with 21% of patients reaching this treatment.
3

Prescription copays were linked to lower rates of quadruple therapy, with priority group 1 patients having higher achievement rates.
4

Adjusted rates of quadruple therapy were higher among Black and Hispanic patients compared to White patients.
5

Inpatient diagnosis was associated with a 50% lower likelihood of achieving quadruple therapy within 6 months.

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