Induced diabetic neurogenic bladder animal models: application characteristics and standardization proposals via systematic data mining - Takeaways - MDSpire

Induced diabetic neurogenic bladder animal models: application characteristics and standardization proposals via systematic data mining

  • By

  • Aihong Jin

  • Xiankang Shao

  • Xiaoping Liang

  • Bowen Xing

  • Simin Qin

  • Yujun He

  • July 7, 2026

  • 0 min

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  • 1

    Diabetic Neurogenic Bladder (DNB) is a common complication of diabetes mellitus, affecting 40%-60% of diabetic patients.

  • 2

    Current DNB animal models lack standardized protocols, leading to inconsistencies in research findings and methodologies.

  • 3

    The study analyzed 352 eligible studies, identifying SD rats, Wistar rats, and C57BL/6 mice as primary animal models for DNB.

  • 4

    Chemical induction, mainly using streptozotocin (STZ), was the most common modeling method, with a typical dose of 60 mg/kg.

  • 5

    Future research should focus on optimizing DNB modeling protocols and enhancing the standardization of reporting study details.

Original Source(s)

Induced diabetic neurogenic bladder animal models: application characteristics and standardization proposals via systematic data mining

  • by Aihong Jin, Xiankang Shao, Xiaoping Liang, Bowen Xing, Simin Qin, Yujun He

  • July 7, 2026

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