Advances in the prevention and treatment of radiation-induced brain necrosis: a narrative review - Takeaways - MDSpire

Advances in the prevention and treatment of radiation-induced brain necrosis: a narrative review

  • By

  • Zhihong Zhao

  • Wan He

  • Jinquan Xia

  • Xiangcheng Wang

  • Guixiang Liao

  • June 29, 2026

  • 0 min

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  • 1

    Radiation-induced brain necrosis (RBN) occurs in 5–25% of patients undergoing radiotherapy for intracranial and head and neck cancers.

  • 2

    Key pathogenesis factors for RBN include vascular injury and neuroinflammation, leading to cognitive impairment and neurological deficits.

  • 3

    Recent preventive strategies for RBN involve advanced radiotherapy techniques and pharmacological agents like bevacizumab and neuroprotective agents.

  • 4

    Treatment options for symptomatic RBN range from corticosteroids and bevacizumab to hyperbaric oxygen therapy and surgical interventions.

  • 5

    Innovations in imaging techniques, such as MRS and PET/CT, enhance early detection and differentiation of RBN from tumor progression.

Original Source(s)

Advances in the prevention and treatment of radiation-induced brain necrosis: a narrative review

  • by Zhihong Zhao, Wan He, Jinquan Xia, Xiangcheng Wang, Guixiang Liao

  • June 29, 2026

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