Partial Oral Versus Intravenous Antibiotic Therapy for Endocarditis With Management by a Multidisciplinary Team: A Retrospective Cohort Study - Takeaways - MDSpire

Partial Oral Versus Intravenous Antibiotic Therapy for Endocarditis With Management by a Multidisciplinary Team: A Retrospective Cohort Study

  • By

  • Sami El-Dalati

  • Bennett Collis

  • Takaaki Kobayashi

  • Evan Hall

  • Talal Alnabelsi

  • Chloe Cao

  • Meredith Johnson

  • John Gurley

  • Luke Strnad

  • Corey Adams

  • Victoria Weaver

  • Hassan Reda

  • Michael Sekela

  • Tessa London

  • Kara Kennedy

  • Armaghan-E Rehman Mansoor

  • David Olafsson

  • Grant Laugherty

  • Alyssa Tremblay

  • Angella Linder

  • Deborah Gill

  • Nicholas J Van Sickels

  • Alexander Pomakov

  • William Harris

  • Bobbi Jo Stoner

  • October 28, 2025

  • 0 min

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  • 1

    A retrospective study evaluated outcomes of infective endocarditis patients treated with intravenous or partial oral antibiotics.

  • 2

    Of 236 patients, 143 received IV therapy alone, while 93 were transitioned to partial oral therapy with similar baseline characteristics.

  • 3

    There were no significant differences in 90-day relapsed infection or all-cause mortality between the two treatment groups.

  • 4

    Oral therapy was not associated with increased 90-day mortality, with independent predictors including older age and acute heart failure.

  • 5

    Partial oral therapy for infective endocarditis appears safe and effective, aligning with European guidelines, particularly in a multidisciplinary setting.

Original Source(s)

Partial Oral Versus Intravenous Antibiotic Therapy for Endocarditis With Management by a Multidisciplinary Team: A Retrospective Cohort Study

  • by Sami El-Dalati, Bennett Collis, Takaaki Kobayashi, Evan Hall, Talal Alnabelsi, Chloe Cao, Meredith Johnson, John Gurley, Luke Strnad, Corey Adams, Victoria Weaver, Hassan Reda, Michael Sekela, Tessa London, Kara Kennedy, Armaghan-E Rehman Mansoor, David Olafsson, Grant Laugherty, Alyssa Tremblay, Angella Linder, Deborah Gill, Nicholas J Van Sickels, Alexander Pomakov, William Harris, Bobbi Jo Stoner

  • October 28, 2025

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