Primary central nervous system lymphoma and tumefactive demyelinating lesions in multiple sclerosis: a retrospective observational cohort study - Takeaways - MDSpire

Primary central nervous system lymphoma and tumefactive demyelinating lesions in multiple sclerosis: a retrospective observational cohort study

  • By

  • Yushan Chen

  • Lvying Shen

  • Shaoqiang Chen

  • Shunyong Zheng

  • Jianmin Xie

  • Shuishun Zheng

  • May 29, 2026

  • 0 min

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  • 1

    The study analyzed 183 patients, including 97 with primary central nervous system lymphoma (PCNSL) and 86 with tumefactive demyelinating lesions (TDLs).

  • 2

    PCNSL patients had a mean onset age of 59 years, significantly older than the 36 years in TDL patients (p < 0.001).

  • 3

    MRI revealed U-shaped hyperintense lesions in PCNSL, while TDLs showed slightly diffuse hyperintense lesions on diffusion-weighted imaging.

  • 4

    Pathological analysis indicated strong CD20 positivity and negative CD3 in PCNSL, contrasting with lower CD20 and stronger CD3 in TDLs.

  • 5

    Cerebrospinal fluid levels of IL-6 and IL-10 were higher in PCNSL compared to TDLs, aiding in differential diagnosis.

Original Source(s)

Primary central nervous system lymphoma and tumefactive demyelinating lesions in multiple sclerosis: a retrospective observational cohort study

  • by Yushan Chen, Lvying Shen, Shaoqiang Chen, Shunyong Zheng, Jianmin Xie, Shuishun Zheng

  • May 29, 2026

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