The FUEL FALD Study: Effects of Udenafil on Liver Stiffness and Fibrosis after Fontan - Takeaways - MDSpire

The FUEL FALD Study: Effects of Udenafil on Liver Stiffness and Fibrosis after Fontan

  • By

  • Kurt R. Schumacher

  • Jonathan Dillman

  • David J. Goldberg

  • Mark Cartoski

  • Michael DiMaria

  • Benjamin Frischhertz

  • Salil Ginde

  • Bryan H. Goldstein

  • Nagraj Kasi

  • Christine K. Lee

  • Daniel H. Leung

  • Chad Y. Mao

  • Brian W. McCrindle

  • Shaji Menon

  • Matthew O’Connor

  • Alexander R. Opotowsky

  • Joseph Palermo

  • Stephen M. Paridon

  • Daniel Penny

  • Rahul Rathod

  • Jonathan B. Wagner

  • Angela Yetman

  • Victor Zak

  • Mark Russell

  • June 20, 2026

  • 0 min

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  • 1

    The FUEL FALD trial investigates the impact of udenafil on liver stiffness and fibrosis in patients post-Fontan surgery.

  • 2

    Fontan-associated liver disease (FALD) results from chronic hepatic venous hypertension and can lead to severe liver complications.

  • 3

    The study utilizes ultrasound shear wave elastography (SWE), magnetic resonance elastography (MRE), and the Enhanced Liver Fibrosis (ELF) score as biomarkers.

  • 4

    Participants in the study were aged 12-20 years and had undergone Fontan surgery before 5 years of age.

  • 5

    Udenafil was administered at a dose of 87.5 mg twice daily over a 12-month period to assess its effects on liver fibrosis.

Original Source(s)

The FUEL FALD Study: Effects of Udenafil on Liver Stiffness and Fibrosis after Fontan

  • by Kurt R. Schumacher, Jonathan Dillman, David J. Goldberg, Mark Cartoski, Michael DiMaria, Benjamin Frischhertz, Salil Ginde, Bryan H. Goldstein, Nagraj Kasi, Christine K. Lee, Daniel H. Leung, Chad Y. Mao, Brian W. McCrindle, Shaji Menon, Matthew O’Connor, Alexander R. Opotowsky, Joseph Palermo, Stephen M. Paridon, Daniel Penny, Rahul Rathod, Jonathan B. Wagner, Angela Yetman, Victor Zak, Mark Russell

  • June 20, 2026

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