Persistent intrahepatic cholestasis secondary to multiple etiologies: a case report - Takeaways - MDSpire

Persistent intrahepatic cholestasis secondary to multiple etiologies: a case report

  • By

  • Ran Wang

  • Yiyang Shang

  • Cai’e Wang

  • Yanhong Gao

  • Wenxiu Zhang

  • Fangbo Gao

  • Yang Guo

  • Baocheng Deng

  • Wenwen Zhang

  • Xingshun Qi

  • June 25, 2026

  • 0 min

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  • 1

    A 42-year-old man with adult-onset Still’s disease developed persistent severe intrahepatic cholestasis due to multiple overlapping causes.

  • 2

    Initial cholestasis was attributed to severe liver injury from adult-onset Still’s disease and possible drug-induced liver injury.

  • 3

    Sepsis developed, potentially linked to glucocorticoid use and central venous catheter contamination, worsening intrahepatic cholestasis.

  • 4

    The patient's condition improved after catheter removal and targeted antibiotic therapy, highlighting the need for etiological reassessment.

  • 5

    Persistent cholestasis led to recommendations for liver transplantation, which the patient declined.

Original Source(s)

Persistent intrahepatic cholestasis secondary to multiple etiologies: a case report

  • by Ran Wang, Yiyang Shang, Cai’e Wang, Yanhong Gao, Wenxiu Zhang, Fangbo Gao, Yang Guo, Baocheng Deng, Wenwen Zhang, Xingshun Qi

  • June 25, 2026

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